Chargers - Giants: Week 5 score, highlights

Report | Olivier Vernon likely out vs Chargers

Left tackle Ereck Flowers and Hart will face the game's most lopsided mismatch as Chargers rushers Joey Bosa and Melvin Ingram take aim at Eli Manning.

Los Angeles punched right back with a touchdown on their first possession of the second quarter.

Manning responded on the very next drive, facing down a blitz, stepping up in the pocket and hitting a wide-open Beckham, who meandered past the pinching secondary, for a 48-yard strike less than two minutes into the fourth. Giants RB Orleans Darkwa's 23-yard touchdown is the longest of his career.

Manning has led the team to a pair of Super Bowl titles since taking over the quarterback duties in NY, defeating the Patriots twice in two tries.

The Chargers (1-4) finally got on the board in the second quarter thanks in part to 20 penalty yards racked up by the Giants defense that included a 15-yard unsportsmanlike call against linebacker B.J. Goodson.

Harris' departure from the game followed injuries to Brandon Marshall and Sterling Shepard. Rivers now has 47,198 passing yards for his career.

More news: Spacewalking astronauts making repairs on International Space Station in October

Los Angeles Chargers wide receiver Mike Williams (back) will make his National Football League debut against the Oakland Raiders in Week 6 according to ESPN's Adam Schefter.

After Sunday afternoon, he still hasn't as the Giants dropped to 0-5 this season in a 27-22 loss.

The Chargers trailed the Giants, 9-0, after the first quarter. It was the Giants' first rushing touchdown of the season by a running back.

Prior to Darkwa's score, the Giants got a safety when Chargers center Spencer Pulley snapped the ball before Rivers was ready.

In the battle of quarterbacks drafted and traded for each other in 2004, Rivers was 21 of 44 for 258 yards with the three TDs and one INT. Manning was 21 of 36 for 225 yards and two TDs and the one INT.

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