Scientists have come up with a new classification of diabetes

The study could not confirm if the five types have different causes nor if patients’ type changes over time

Recasting adult-onset diabetes into five types could help better tailor early treatment for patients, said the research by scientists from Lund University Diabetes Centre, Sweden, and Institute for Molecular Medicine Finland.

In their analysis of nearly 9000 patients with adult-onset diabetes, they identified five replicable clusters of disease, each with significantly different characteristics and risk of complications.

Cluster 5 (39.1 percent): Mild age-related diabetes, older than patients in other clusters and only modest metabolic derangements.

Type 1 diabetes - generally diagnosed in childhood - is caused by the body's immune system destroying the cells that release insulin, eventually ending insulin production from the body. Clinical characteristics included early-onset of the disease and being GADA positive, along with a lower BMI, poor metabolic control, and insulin deficiency. Similar to cluster 1 patients, this group includes young people of a healthy weight whose bodies do not produce insulin properly.

Cluster 2 was mainly defined as severely insulin-deficient as well as GADA negative. Diabetic eye disease was most common in this group.

The third cluster, accounting for 15.3% of the cohort, was marked by both a high degrees of insulin resistance - specifically a high HOMA2-IR index - paired with a high BMI. This group had a low proportion of patients taking metformin, although the authors say they would be expected to benefit the most from the drug.

Another mild diabetes form related to obesity (affecting between 18 and 23 percent of the cases).

More news: 7.5 magnitude quake strikes Papua New Guinea

Still, the findings seem to be a positive step toward improved treatment of diabetes, which affects more than 420 million people worldwide. They explain that this method of classification could also be used in clinical trials for drugs used in diabetics for better results and deeper understanding of the mechanism of action of the drugs.

The other severe category, called severe insulin-resistant diabetes, is linked to obesity and shows a strong tendency for the body's cells not to respond to insulin, with these patients showing the highest likelihood of having liver disease, chronic kidney disease, and diabetic kidney disease.

Almost 15,000 patients in Sweden and Finland were monitored for a variety of factors, including age at diagnosis, body-mass index, long-term glycemic control, functioning of insulin production in the pancreas, insulin resistance, the detection of auto-antibodies, genetic analyses, disease progression, complications, and treatment success.

Researchers did not observe between-cluster differences for age- and sex-adjusted coronary event and stroke risk, and no genetic variant was associated with all the clusters. Instead, several genes were only associated with certain clusters.

Rob Sladek, MD, of McGill University, Montral, wrote an accompanying editorial with this landmark paper. The new study, she said, could help lead scientists towards a diabetes cure by changing the way they approach future study.

Diabetes: it's a life-long health condition, and it's on the rise. They're now working on a web-based tool that could assign patients to specific clusters. Further larger studies with diverse populations may be necessary before these results can be generalized. This project also received funding from the Innovative Medicines Initiative 2 Joint Undertaking and by the Swedish Foundation for Strategic Research.

The researchers identified 5 main disease clusters.

Related News:

Most liked

President Ghani of Afghanistan offers Taliban a political path to peace
The Afghan Taliban on Monday calls on the start a direct dialogue towards for "a peaceful solution". He said, "We are making this offer without preconditions in order to lead to a peace agreement".

WHITE HOUSE STAFFING: Spokeswoman says McMaster 'isn't going anywhere'
The Post report quoted unnamed U.S. officials familiar with intelligence reports on the issue. The White House, however, maintained that the meeting was strictly diplomatic.

Samsung Galaxy S9+ bags the top spot on DxOMark
It recently continued the trend and claimed that there were better-sounding smartphone speakers than HomePod. Quite simply it means the S9 now lets in more light than any other phone in the world.

Cavs suspend JR Smith due to 'detrimental conduct'
National Basketball Association fans woke up Friday morning to a peculiar story surrounding Cleveland Cavaliers J.R. Surprisingly, though, Smith hasn't anxious about losing his starting role since the Cavs first game of the season.

Boston Red Sox announce that JD Martinez is official member of team
To play in front of fans that are just as passionate and love it just as much, it's exciting". "He's a complete hitter". He did an outstanding job a year ago with the D-backs and that's also something he's going to bring.

Here are Warren Buffett's 15 biggest stock investments
It was a note of caution that may reverberate as investors weigh whether the bull market will resume after this month's sell-off. Warren Buffett does not own a smartphone - and doesn't plan to for a long time - but he loves his Apple shares .

United Nations report links North Korea to Syria's chemical weapons program
If the account of activities detailed in the United Nations report are true, she said, "it shows the depravity of the regime". North Korea is already under a range of global and USA sanctions over its nuclear programme and missile tests.

Russian Federation vetoes United Nations resolution to call out Iran over Yemen
Haley stated, "Russia has repeatedly stopped the Security Council from acting against the barbaric Assad regime in Syria". It received 11 votes in favor, two against - Russian Federation and Bolivia - while China and Kazakhstan abstained .

Shahbaz Sharif elected un-opposed acting President of PML-N
The party will also hold another meeting on March 6 for intraparty elections to elect Shahbaz Sharif as the permanent president. While speaking to the media, Kaira said Shehbaz was on good terms with the bureaucracy but had been disrespectful towards PPP.

Nassar and Rajini in Mumbai, Kamal Haasan takes the evening flight!
In his condolence message through a video release, Kamal, who acted in 37 films with her, recounted his memories with her. Her film with debutant director Bharathiraaja titled Pathinaru Vayadhinile was entirely a different kettle of fish.

New Yorker arrested in Japan over severed head in suitcase
Police have reportedly described the body parts as having no apparent injuries apart from where they were severed. The man was arrested for allegedly "confining" the woman in an apartment in Osaka, the Japan Times reported.

President Trump to attend Graham's funeral
His autobiography, "Just As I Am", published in 1997 appeared simultaneously on the three top best-seller lists in one week. The Charlotte-born preacher died Wednesday at his home in Montreat at age 99. "It's just memories", Hernandez said.

ESPN's Six Nations review: Player of the weekend, flop and more
The video shows Farrell shoving Wilson just after the Scot appeared to try and speak to England first five-eighth George Ford. Every player from both teams, when asked what happened, denied any knowledge of it.

PM Back To New Deputy
INITIAL 6.30am: Member for Maranoa David Littleproud has announced he will not vie for the position of Deputy Prime Minister. He is, of course, taking over from Barnaby Joyce .

Small plane goes missing after takeoff from Grand Junction airport
According to Jon Kaupp, the four missing men included his father, Bill Kaupp and brother, Clint Kaupp, from New Dayton. On Thursday morning, the plane took off again en route to Albuquerque.